Cstb | cystatin B

GeneMGI:109514Synonyms: Stfb

Physiological systems

17 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Limbs/digits/tail Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Skeleton

8 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal auditory brainstem response	1 supporting dataset	Cstb^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.9x10^-6
decreased total retina thickness	2 supporting datasets	Cstb^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.26x10^-14
decreased circulating creatinine level	1 supporting dataset	Cstb^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.46x10^-5
abnormal retina outer nuclear layer morphology	4 supporting datasets	Cstb^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.15x10^-13
hyperactivity	3 supporting datasets	Cstb^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.29x10^-5
decreased body length	1 supporting dataset	Cstb^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.76x10^-5
increased monocyte cell number	2 supporting datasets	Cstb^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.76x10^-10
increased circulating triglyceride level	1 supporting dataset	Cstb^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.89x10^-5
increased vertical activity	1 supporting dataset	Cstb^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.61x10^-7
short tibia	2 supporting datasets	Cstb^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.09x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cstb.

Associated images

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Histopathology

There is no histopathology data found for Cstb.

IMPC related publications

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External links

No external links available for Cstb.

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*Cstb^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cstb^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cstb^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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