Cstb | cystatin B
Physiological systems
17 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Limbs/digits/tail Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Skeleton
8 No significant impact
7 Not tested
Data collections
Gene metrics:12Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal auditory brainstem response | 1 supporting dataset | Cstbtm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.9x10-6 | ||
| decreased total retina thickness | 2 supporting datasets | Cstbtm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.26x10-14 | ||
| decreased circulating creatinine level | 1 supporting dataset | Cstbtm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.46x10-5 | ||
| abnormal retina outer nuclear layer morphology | 4 supporting datasets | Cstbtm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.15x10-13 | ||
| hyperactivity | 3 supporting datasets | Cstbtm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.29x10-5 | ||
| decreased body length | 1 supporting dataset | Cstbtm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.76x10-5 | ||
| increased monocyte cell number | 2 supporting datasets | Cstbtm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.76x10-10 | ||
| increased circulating triglyceride level | 1 supporting dataset | Cstbtm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.89x10-5 | ||
| increased vertical activity | 1 supporting dataset | Cstbtm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.61x10-7 | ||
| short tibia | 2 supporting datasets | Cstbtm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.09x10-7 |
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Human diseases caused by Cstb mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cstb.
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| Cstbtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cstbtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cstbtm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |