Itga8 | integrin alpha 8

GeneMGI:109442

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:48Adult tissues

51Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Itga8^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased grip strength	1 supporting dataset	Itga8^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.37x10^-5
increased circulating free fatty acids level	1 supporting dataset	Itga8^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	9.56x10^-5
decreased circulating glucose level	1 supporting dataset	Itga8^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.79x10^-5
increased circulating sodium level	1 supporting dataset	Itga8^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.54x10^-6
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Itga8^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.49x10^-5
increased mean corpuscular volume	1 supporting dataset	Itga8^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.13x10^-6
increased circulating calcium level	1 supporting dataset	Itga8^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.51x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Itga8.

Associated images

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Histopathology

There is no histopathology data found for Itga8.

IMPC related publications

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External links

No external links available for Itga8.

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*Itga8^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	ES Cell mouse
*Itga8^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Itga8^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Itga8^{tm39262(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Itga8^{tm39262(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Itga8^{tm39262(L1L2_Pgk_PM)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Itga8^{tm39262(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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