Nek2 | NIMA (never in mitosis gene a)-related expressed kinase 2
GeneMGI:109359
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hearing/vestibular/ear Behavior/neurological Cardiovascular system Renal/urinary system
11 No significant impact
6 Not tested
Data collections
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| abnormal kidney morphology | 1 supporting dataset | Nek2em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| abnormal locomotor behavior | 1 supporting dataset | Nek2tm1b(KOMP)Wtsi | homozygote | Early adult | 5.17x10-5 | ||
| abnormal auditory brainstem response | 2 supporting datasets | Nek2tm1b(KOMP)Wtsi | homozygote | Early adult | 5.39x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Nek2tm1b(KOMP)Wtsi | homozygote | Early adult | 3.25x10-6 | ||
| increased heart weight | 1 supporting dataset | Nek2tm1b(KOMP)Wtsi | homozygote | Early adult | 3.94x10-5 | ||
| enlarged lymph nodes | 1 supporting dataset | Nek2em1(IMPC)Tcp | homozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | Section images | 0% (0/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Nek2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Nek2.
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| Nek2em1(IMPC)Tcp | Indel | | mouse |
| Nek2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Nek2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |