Nek2 | NIMA (never in mitosis gene a)-related expressed kinase 2
GeneMGI:109359
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hearing/vestibular/ear Behavior/neurological Cardiovascular system Renal/urinary system
11 No significant impact
6 Not tested
Data collections
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| abnormal kidney morphology | 1 supporting dataset | Nek2em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| abnormal locomotor behavior | 1 supporting dataset | Nek2tm1b(KOMP)Wtsi | homozygote | Early adult | 5.17x10-5 | ||
| abnormal auditory brainstem response | 2 supporting datasets | Nek2tm1b(KOMP)Wtsi | homozygote | Early adult | 5.39x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Nek2tm1b(KOMP)Wtsi | homozygote | Early adult | 3.25x10-6 | ||
| increased heart weight | 1 supporting dataset | Nek2tm1b(KOMP)Wtsi | homozygote | Early adult | 3.94x10-5 | ||
| enlarged lymph nodes | 1 supporting dataset | Nek2em1(IMPC)Tcp | homozygote | Early adult | N/A * |
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External links
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| Nek2em1(IMPC)Tcp | Indel | | mouse |
| Nek2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Nek2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |