Nxn | nucleoredoxin
Physiological systems
24 / 24 physiological systems tested
17 Significantly impacted by the knock-out
Immune system Endocrine/exocrine gland Integument Growth/size/body region Digestive/alimentary Muscle Hematopoietic system Craniofacial Cardiovascular system Homeostasis/metabolism Embryo Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging
7 No significant impact
Gene metrics:39Significant phenotypes
2Associated diseases
Expression examined in:82Adult tissues
114Embryo tissues
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Nxntm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal head shape | 2 supporting datasets | Nxntm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| abnormal mammary gland morphology | 1 supporting dataset | Nxntm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Nxnem1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| abnormal facial morphology | 5 supporting datasets | Nxntm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Nxnem1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| cleft palate | 2 supporting datasets | Nxntm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Nxnem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal facial morphology | 2 supporting datasets | Nxnem1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| spina bifida | 1 supporting dataset | Nxnem1(IMPC)Mbp | homozygote | E15.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images Wholemount images | 88.24% (15/17) | 0.7% (4/570) |
| aorta | heterozygote | Section images Wholemount images | 88.24% (15/17) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| blood vessel | heterozygote | n/a | 100% (2/2) | 0% (0/173) |
| bone | heterozygote | Section images Wholemount images | 50% (4/8) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Section images Wholemount images | 100% (18/18) | 0.86% (5/579) |
| brainstem | heterozygote | Section images Wholemount images | 85.71% (12/14) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images Wholemount images | 12.5% (2/16) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images Wholemount images | 85.71% (12/14) | 0.22% (1/454) |
Human diseases caused by Nxn mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Nxn.
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| Nxnem1(IMPC)Bay | Exon Deletion | | mouse |
| Nxnem1(IMPC)J | Indel | | mouse |
| Nxnem1(IMPC)Mbp | Insertion | | mouse |
| Nxntm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Nxntm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Nxntm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Nxntm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Nxntm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |