Nxn | nucleoredoxin

GeneMGI:109331Synonyms: l11Jus13

Physiological systems

24 / 24 physiological systems tested

17 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Integument Growth/size/body region Digestive/alimentary Muscle Hematopoietic system Craniofacial Cardiovascular system Homeostasis/metabolism Embryo Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging

7 No significant impact

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:39Significant phenotypes

2Associated diseases

Expression examined in:82Adult tissues

114Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



preweaning lethality, incomplete penetrance	3 supporting datasets	Nxn^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal head shape	2 supporting datasets	Nxn^{tm1b(EUCOMM)Wtsi}	homozygote	E18.5	N/A ^*
abnormal mammary gland morphology	1 supporting dataset	Nxn^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Nxn^em1(IMPC)Bay	homozygote	E18.5	N/A ^*
abnormal facial morphology	5 supporting datasets	Nxn^{tm1b(EUCOMM)Wtsi}	homozygote	E18.5	N/A ^*
hemorrhage	1 supporting dataset	Nxn^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
cleft palate	2 supporting datasets	Nxn^{tm1b(EUCOMM)Wtsi}	homozygote	E18.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Nxn^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal facial morphology	2 supporting datasets	Nxn^em1(IMPC)Bay	homozygote	E18.5	N/A ^*
spina bifida	1 supporting dataset	Nxn^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nxn.

Associated images

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Histopathology

There is no histopathology data found for Nxn.

IMPC related publications

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External links

No external links available for Nxn.

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*Nxn^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Nxn^em1(IMPC)J*	Indel	‌	mouse
*Nxn^em1(IMPC)Mbp*	Insertion	‌	mouse
*Nxn^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nxn^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nxn^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Nxn^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Nxn^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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