Lama4 | laminin, alpha 4

GeneMGI:109321Synonyms: laminin [a]4

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Integument Growth/size/body region Vision/eye Hematopoietic system Cardiovascular system Mortality/aging

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal coat/hair pigmentation	1 supporting dataset	Lama4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.27x10^-8
increased basophil cell number	1 supporting dataset	Lama4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.56x10^-6
increased heart weight	2 supporting datasets	Lama4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.9x10^-9
abnormal skin morphology	1 supporting dataset	Lama4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
cornea opacity	1 supporting dataset	Lama4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.78x10^-6
preweaning lethality, incomplete penetrance	1 supporting dataset	Lama4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Lama4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.67x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lama4.

Associated images

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Histopathology

There is no histopathology data found for Lama4.

IMPC related publications

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External links

No external links available for Lama4.

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*Lama4^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Lama4^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Lama4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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