Sema4d | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

GeneMGI:109244Synonyms: semaphorin H, Semacl2, +5 more

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Skeleton Cardiovascular system

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



cataract	1 supporting dataset	Sema4d^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.75x10^-6
enlarged heart	1 supporting dataset	Sema4d^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased total body fat amount	1 supporting dataset	Sema4d^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.61x10^-5
enlarged spleen	1 supporting dataset	Sema4d^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Sema4d^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.28x10^-7
decreased bone mineral content	1 supporting dataset	Sema4d^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.76x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sema4d.

Associated images

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Histopathology

There is no histopathology data found for Sema4d.

IMPC related publications

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External links

No external links available for Sema4d.

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*Sema4d^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Sema4d^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sema4d^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Sema4d^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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