Pkn2 | protein kinase N2

GeneMGI:109211Synonyms: Prkcl2, PRK2, +2 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased exploration in new environment	1 supporting dataset	Pkn2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.63x10^-11
increased circulating bilirubin level	1 supporting dataset	Pkn2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.8x10^-6
decreased circulating HDL cholesterol level	1 supporting dataset	Pkn2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.79x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Pkn2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating cholesterol level	1 supporting dataset	Pkn2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.59x10^-5
decreased circulating unsaturated transferrin level	1 supporting dataset	Pkn2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.18x10^-7
increased startle reflex	1 supporting dataset	Pkn2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.18x10^-9
decreased circulating total protein level	1 supporting dataset	Pkn2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.4x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pkn2.

Associated images

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Histopathology

There is no histopathology data found for Pkn2.

IMPC related publications

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External links

No external links available for Pkn2.

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*Pkn2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pkn2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pkn2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Pkn2^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Pkn2^{tm3a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Pkn2^{tm3e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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