Eif4g2 | eukaryotic translation initiation factor 4, gamma 2

GeneMGI:109207Synonyms: DAP-5, Nat1, +2 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Skeleton Mortality/aging

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased fasting circulating glucose level	1 supporting dataset	Eif4g2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.14x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Eif4g2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased bone mineral content	2 supporting datasets	Eif4g2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.49x10^-7
abnormal bone structure	1 supporting dataset	Eif4g2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.62x10^-6
hyperactivity	3 supporting datasets	Eif4g2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.8x10^-5
decreased bone mineral density	1 supporting dataset	Eif4g2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.33x10^-8
decreased circulating chloride level	1 supporting dataset	Eif4g2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.65x10^-7
decreased circulating glucose level	1 supporting dataset	Eif4g2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.09x10^-6
embryonic lethality prior to organogenesis	1 supporting dataset	Eif4g2^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Eif4g2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.47x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Eif4g2.

Associated images

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Histopathology

There is no histopathology data found for Eif4g2.

IMPC related publications

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External links

No external links available for Eif4g2.

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*Eif4g2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Eif4g2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Eif4g2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Eif4g2^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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