Ltbp1 | latent transforming growth factor beta binding protein 1

GeneMGI:109151Synonyms: Ltbp1L, LTBP-1, +2 more

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Growth/size/body region Limbs/digits/tail Hematopoietic system Skeleton Craniofacial Cardiovascular system

10 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal cranium morphology	1 supporting dataset	Ltbp1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.87x10^-12
abnormal snout morphology	1 supporting dataset	Ltbp1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.25x10^-12
decreased body weight	4 supporting datasets	Ltbp1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.03x10^-13
abnormal ulna morphology	1 supporting dataset	Ltbp1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.33x10^-11
abnormal incisor morphology	1 supporting dataset	Ltbp1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.73x10^-6
abnormal radius morphology	1 supporting dataset	Ltbp1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.77x10^-12
increased hemoglobin content	1 supporting dataset	Ltbp1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.23x10^-5
increased circulating bilirubin level	1 supporting dataset	Ltbp1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.64x10^-5
abnormal tooth morphology	1 supporting dataset	Ltbp1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.65x10^-10
vertebral fusion	1 supporting dataset	Ltbp1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.49x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ltbp1.

Associated images

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Histopathology

There is no histopathology data found for Ltbp1.

IMPC related publications

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External links

No external links available for Ltbp1.

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*Ltbp1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse

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