Meis3 | Meis homeobox 3

GeneMGI:108519Synonyms: Mrg2

Physiological systems

21 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Hematopoietic system Craniofacial Renal/urinary system Homeostasis/metabolism Vision/eye Liver/biliary system Respiratory system Behavior/neurological Skeleton

7 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

0Associated diseases

Expression examined in:78Adult tissues

36Embryo tissues

Phenotypes

Phy. System:



abnormal tooth morphology	1 supporting dataset	Meis3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased lung elastance	4 supporting datasets	Meis3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.14x10^-5
small liver	1 supporting dataset	Meis3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
cystolithiasis	1 supporting dataset	Meis3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Meis3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Meis3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
impaired glucose tolerance	1 supporting dataset	Meis3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.03x10^-7
abnormal seminal vesicle morphology	1 supporting dataset	Meis3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal tooth color	1 supporting dataset	Meis3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Meis3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Meis3.

Associated images

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Histopathology

There is no histopathology data found for Meis3.

IMPC related publications

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External links

No external links available for Meis3.

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*Meis3^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Meis3^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Meis3^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Meis3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Meis3^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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