Lpar1 | lysophosphatidic acid receptor 1

GeneMGI:108429Synonyms: LPA1, Edg2, +3 more

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Mortality/aging

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:



improved glucose tolerance	1 supporting dataset	Lpar1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.88x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Lpar1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased fasting circulating glucose level	1 supporting dataset	Lpar1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.72x10^-9
cataract	1 supporting dataset	Lpar1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.51x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lpar1.

Associated images

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Histopathology

There is no histopathology data found for Lpar1.

IMPC related publications

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External links

No external links available for Lpar1.

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*Lpar1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Lpar1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Lpar1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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