Nfe2l2 | nuclear factor, erythroid derived 2, like 2
Physiological systems
22 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Hematopoietic system Skeleton Craniofacial
13 No significant impact
2 Not tested
Data collections
Gene metrics:21Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal lymph node morphology | 2 supporting datasets | Nfe2l2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Nfe2l2em1(IMPC)Ccpcz | homozygote | Early adult | 4.53x10-5 | ||
| abnormal seminal vesicle morphology | 1 supporting dataset | Nfe2l2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased mean platelet volume | 1 supporting dataset | Nfe2l2em1(IMPC)Ccpcz | homozygote | Early adult | 6.72x10-8 | ||
| enlarged lymph nodes | 1 supporting dataset | Nfe2l2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 2 supporting datasets | Nfe2l2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Nfe2l2em1(IMPC)Ccpcz | homozygote | Early adult | 7.26x10-6 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Nfe2l2em1(IMPC)Ccpcz | homozygote | Early adult | 9.86x10-6 | ||
| increased circulating lactate dehydrogenase level | 1 supporting dataset | Nfe2l2em1(IMPC)Ccpcz | homozygote | Early adult | 1.72x10-5 | ||
| abnormal thymus morphology | 1 supporting dataset | Nfe2l2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by Nfe2l2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Nfe2l2.
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| Nfe2l2em1(IMPC)Ccpcz | Intra-exon deletion | | mouse |
| Nfe2l2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Nfe2l2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Nfe2l2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Nfe2l2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |