Ptpn18 | protein tyrosine phosphatase, non-receptor type 18
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Vision/eye Hematopoietic system Mortality/aging Cardiovascular system
12 No significant impact
7 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| persistence of hyaloid vascular system | 1 supporting dataset | Ptpn18em1(IMPC)J | heterozygote | Early adult | 5.94x10-8 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Ptpn18em1(IMPC)J | heterozygote | Early adult | 4.92x10-5 | ||
| prolonged RR interval | 1 supporting dataset | Ptpn18em1(IMPC)J | homozygote | Early adult | 3.34x10-5 | ||
| abnormal placement of pupils | 1 supporting dataset | Ptpn18em1(IMPC)J | heterozygote | Early adult | 7.9x10-5 | ||
| cataract | 1 supporting dataset | Ptpn18em1(IMPC)J | heterozygote | Early adult | 4.47x10-6 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Ptpn18em1(IMPC)J | homozygote | Early adult | N/A * | ||
| increased leukocyte cell number | 1 supporting dataset | Ptpn18em1(IMPC)J | homozygote | Early adult | 6.15x10-5 | ||
| decreased heart rate | 1 supporting dataset | Ptpn18em1(IMPC)J | homozygote | Early adult | 7.96x10-6 |
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External links
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| Ptpn18em1(IMPC)J | Exon Deletion | | mouse |
| Ptpn18tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Ptpn18tm51109(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |