Hdac1 | histone deacetylase 1

GeneMGI:108086Synonyms: HD1, RPD3, +1 more

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system

17 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



cardiovascular system phenotype	1 supporting dataset	Hdac1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.03x10^-5
decreased mean corpuscular hemoglobin	1 supporting dataset	Hdac1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.63x10^-5
decreased exploration in new environment	1 supporting dataset	Hdac1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.73x10^-7
increased circulating cholesterol level	1 supporting dataset	Hdac1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.52x10^-9
preweaning lethality, complete penetrance	1 supporting dataset	Hdac1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating HDL cholesterol level	1 supporting dataset	Hdac1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	8.74x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Hdac1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased heart rate variability	1 supporting dataset	Hdac1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.86x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hdac1.

Associated images

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Histopathology

There is no histopathology data found for Hdac1.

IMPC related publications

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External links

No external links available for Hdac1.

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*Hdac1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Hdac1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Hdac1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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