Cep250 | centrosomal protein 250
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Reproductive system Adipose tissue Hearing/vestibular/ear Behavior/neurological
14 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased total body fat amount | 1 supporting dataset | Cep250tm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.26x10-6 | ||
| abnormal auditory brainstem response | 2 supporting datasets | Cep250tm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.94x10-10 | ||
| absent pinna reflex | 1 supporting dataset | Cep250tm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.03x10-7 | ||
| male infertility | 1 supporting dataset | Cep250tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
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Human diseases caused by Cep250 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cep250.
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| Cep250tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cep250tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |