Smo | smoothened, frizzled class receptor
Physiological systems
23 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Integument Embryo Mortality/aging Cardiovascular system
19 No significant impact
1 Not tested
Gene metrics:9Significant phenotypes
6Associated diseases
Expression examined in:49Adult tissues
62Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Smotm1Amc | homozygote | Early adult | N/A * | ||
| abnormal embryo development | 1 supporting dataset | Smotm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal pericardium morphology | 1 supporting dataset | Smotm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Smotm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Smotm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Smotm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| increased heart rate variability | 1 supporting dataset | Smotm1b(KOMP)Wtsi | heterozygote | Early adult | 2.94x10-5 | ||
| abnormal embryo turning | 1 supporting dataset | Smotm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| decreased heart rate | 1 supporting dataset | Smotm1b(KOMP)Wtsi | heterozygote | Early adult | 6.13x10-7 | ||
| prolonged RR interval | 1 supporting dataset | Smotm1b(KOMP)Wtsi | heterozygote | Early adult | 3.51x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Smo mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Smo.
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| Smotm199121(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Smotm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Smotm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Smotm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |