Smo | smoothened, frizzled class receptor

GeneMGI:108075Synonyms: E130215L21Rik

Physiological systems

23 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Integument Embryo Mortality/aging Cardiovascular system

19 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

6Associated diseases

Expression examined in:49Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	1 supporting dataset	Smo^tm1Amc	homozygote	Early adult	N/A ^*
abnormal embryo development	1 supporting dataset	Smo^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal pericardium morphology	1 supporting dataset	Smo^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Smo^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Smo^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Smo^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
increased heart rate variability	1 supporting dataset	Smo^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.94x10^-5
abnormal embryo turning	1 supporting dataset	Smo^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
decreased heart rate	1 supporting dataset	Smo^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.13x10^-7
prolonged RR interval	1 supporting dataset	Smo^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.51x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Smo.

Associated images

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Histopathology

There is no histopathology data found for Smo.

IMPC related publications

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External links

No external links available for Smo.

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*Smo^{tm199121(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Smo^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Smo^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Smo^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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