Polr1b | polymerase (RNA) I polypeptide B
Physiological systems
22 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Immune system Integument Endocrine/exocrine gland Growth/size/body region Liver/biliary system Hematopoietic system Skeleton Mortality/aging Craniofacial Renal/urinary system
12 No significant impact
2 Not tested
Data collections
Gene metrics:10Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged thymus | 1 supporting dataset | Polr1bem1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| abnormal tooth morphology | 1 supporting dataset | Polr1bem1(IMPC)Tcp | heterozygote | Early adult | 7.38x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Polr1bem1(IMPC)Tcp | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Polr1bem1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| abnormal liver morphology | 1 supporting dataset | Polr1bem1(IMPC)Tcp | heterozygote | Late adult | N/A * | ||
| thick skin | 1 supporting dataset | Polr1bem1(IMPC)Tcp | heterozygote | Late adult | N/A * | ||
| enlarged urinary bladder | 1 supporting dataset | Polr1bem1(IMPC)Tcp | heterozygote | Late adult | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Polr1bem1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| enlarged kidney | 1 supporting dataset | Polr1bem1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Polr1bem1(IMPC)Tcp | heterozygote | Late adult | N/A * |
| | | | | | | | | | |
External links
No external links available for Polr1b.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Polr1bem1(IMPC)Tcp | Exon Deletion | | mouse |
| Polr1btm372681(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |