Sqstm1 | sequestosome 1

GeneMGI:107931Synonyms: A170, p62, +3 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

8Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal behavior	4 supporting datasets	Sqstm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.82x10^-7
decreased circulating LDL cholesterol level	1 supporting dataset	Sqstm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.11x10^-5
decreased circulating HDL cholesterol level	1 supporting dataset	Sqstm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.94x10^-7
decreased hemoglobin content	1 supporting dataset	Sqstm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	9.3x10^-6
decreased circulating cholesterol level	1 supporting dataset	Sqstm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	7.2x10^-7
decreased circulating glucose level	1 supporting dataset	Sqstm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.08x10^-5
decreased mean corpuscular hemoglobin	1 supporting dataset	Sqstm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	6.86x10^-9
decreased mean corpuscular volume	1 supporting dataset	Sqstm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.59x10^-14
increased circulating alkaline phosphatase level	1 supporting dataset	Sqstm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	9.44x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sqstm1.

Associated images

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Histopathology

There is no histopathology data found for Sqstm1.

IMPC related publications

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External links

No external links available for Sqstm1.

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*Sqstm1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Sqstm1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Sqstm1^{tm55708(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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