Tial1 | Tia1 cytotoxic granule-associated RNA binding protein-like 1

GeneMGI:107913Synonyms: mTIAR, 5330433G13Rik, +1 more

Physiological systems

15 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Skeleton

10 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating triglyceride level	1 supporting dataset	Tial1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.15x10^-5
decreased total body fat amount	2 supporting datasets	Tial1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.53x10^-6
thrombocytosis	1 supporting dataset	Tial1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.54x10^-5
increased bone mineral density	1 supporting dataset	Tial1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.55x10^-6
decreased circulating cholesterol level	1 supporting dataset	Tial1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.44x10^-9
decreased circulating HDL cholesterol level	1 supporting dataset	Tial1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.18x10^-8
increased lean body mass	2 supporting datasets	Tial1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.35x10^-6
decreased circulating calcium level	1 supporting dataset	Tial1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.26x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tial1.

Associated images

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Histopathology

There is no histopathology data found for Tial1.

IMPC related publications

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External links

No external links available for Tial1.

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*Tial1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tial1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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