Ndufv1 | NADH:ubiquinone oxidoreductase core subunit V1

GeneMGI:107851Synonyms: 24 kDa (FP)

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

6 Not tested

Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues

Phenotypes

decreased hematocrit1 supporting datasetNdufv1tm1.1(KOMP)VlcgheterozygoteEarly adult1.04x10-6 
decreased erythrocyte cell number1 supporting datasetNdufv1tm1.1(KOMP)VlcgheterozygoteEarly adult4.59x10-8 
hyperactivity1 supporting datasetNdufv1tm1.1(KOMP)VlcgheterozygoteEarly adult8.12x10-5 
preweaning lethality, complete penetrance1 supporting datasetNdufv1tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
embryonic lethality prior to organogenesis1 supporting datasetNdufv1tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
decreased hemoglobin content1 supporting datasetNdufv1tm1.1(KOMP)VlcgheterozygoteEarly adult1.81x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ndufv1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Ndufv1tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Ndufv1tm85611(L1L2_Pgk_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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