Pfkfb2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

GeneMGI:107815Synonyms: PFK-2/FBPase-2 gene B, 4930568D07Rik

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Cardiovascular system

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal retina morphology	1 supporting dataset	Pfkfb2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.47x10^-6
increased lymphocyte cell number	1 supporting dataset	Pfkfb2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.73x10^-5
decreased neutrophil cell number	1 supporting dataset	Pfkfb2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.49x10^-6
thin ventricular wall	1 supporting dataset	Pfkfb2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.69x10^-7
increased basophil cell number	2 supporting datasets	Pfkfb2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.09x10^-18
increased eosinophil cell number	1 supporting dataset	Pfkfb2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.09x10^-6
increased fasting circulating glucose level	1 supporting dataset	Pfkfb2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.65x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pfkfb2.

Associated images

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Histopathology

There is no histopathology data found for Pfkfb2.

IMPC related publications

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External links

No external links available for Pfkfb2.

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*Pfkfb2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pfkfb2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pfkfb2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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