Dync1i2 | dynein cytoplasmic 1 intermediate chain 2

GeneMGI:107750Synonyms: 3110079H08Rik, Dncic2

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Skeleton

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased leukocyte cell number	1 supporting dataset	Dync1i2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	8x10^-6
decreased circulating HDL cholesterol level	1 supporting dataset	Dync1i2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.81x10^-6
increased lean body mass	1 supporting dataset	Dync1i2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.91x10^-7
increased bone mineral content	1 supporting dataset	Dync1i2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.2x10^-5
decreased total body fat amount	1 supporting dataset	Dync1i2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.87x10^-6
decreased circulating cholesterol level	1 supporting dataset	Dync1i2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	8.4x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dync1i2.

Associated images

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Histopathology

There is no histopathology data found for Dync1i2.

IMPC related publications

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External links

No external links available for Dync1i2.

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*Dync1i2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dync1i2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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