Myo10 | myosin X

GeneMGI:107716Synonyms: myosin-X, D15Ertd600e

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Limbs/digits/tail Vision/eye Behavior/neurological Skeleton

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



fused cornea and lens	1 supporting dataset	Myo10^{tm2(KOMP)Wtsi}	homozygote	Early adult	1.39x10^-14
abnormal digit morphology	2 supporting datasets	Myo10^{tm2(KOMP)Wtsi}	homozygote	Early adult	9.06x10^-21
fused phalanges	2 supporting datasets	Myo10^{tm2(KOMP)Wtsi}	homozygote	Early adult	9.06x10^-21
cataract	1 supporting dataset	Myo10^{tm2(KOMP)Wtsi}	homozygote	Early adult	1.19x10^-7
abnormal coat/hair pigmentation	6 supporting datasets	Myo10^{tm2(KOMP)Wtsi}	homozygote	Early adult	1.78x10^-14
abnormal iris morphology	1 supporting dataset	Myo10^{tm2(KOMP)Wtsi}	homozygote	Early adult	5.18x10^-6
persistence of hyaloid vascular system	1 supporting dataset	Myo10^{tm2(KOMP)Wtsi}	homozygote	Early adult	3.04x10^-15
abnormal tail morphology	1 supporting dataset	Myo10^{tm2(KOMP)Wtsi}	homozygote	Early adult	4.78x10^-5
impaired pupillary reflex	1 supporting dataset	Myo10^{tm2(KOMP)Wtsi}	homozygote	Early adult	6.91x10^-6
abnormal cornea morphology	1 supporting dataset	Myo10^{tm2(KOMP)Wtsi}	homozygote	Early adult	3.62x10^-11

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Myo10.

Associated images

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Histopathology

There is no histopathology data found for Myo10.

IMPC related publications

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External links

No external links available for Myo10.

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*Myo10^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Myo10^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Myo10^{tm2(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse
*Myo10^{tm242153(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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