Bckdha | branched chain ketoacid dehydrogenase E1, alpha polypeptide

GeneMGI:107701Synonyms: BCKAD E1[a]

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Hematopoietic system Mortality/aging

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	3 supporting datasets	Bckdha^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
small seminal vesicle	1 supporting dataset	Bckdha^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
increased neutrophil cell number	2 supporting datasets	Bckdha^em1(IMPC)Tcp	heterozygote	Early adult	1.93x10^-16
decreased lymphocyte cell number	1 supporting dataset	Bckdha^em1(IMPC)Tcp	heterozygote	Early adult	3.57x10^-15

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bckdha.

Associated images

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Histopathology

There is no histopathology data found for Bckdha.

IMPC related publications

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External links

No external links available for Bckdha.

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*Bckdha^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Bckdha^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Bckdha^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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