Zfp462 | zinc finger protein 462
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Embryo Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging
13 No significant impact
4 Not tested
Data collections
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Zfp462em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| decreased lean body mass | 2 supporting datasets | Zfp462em1(IMPC)Tcp | heterozygote | Early adult | 1.14x10-10 | ||
| thrombocytopenia | 1 supporting dataset | Zfp462em1(IMPC)Tcp | heterozygote | Early adult | 5.71x10-8 | ||
| edema | 1 supporting dataset | Zfp462em1(IMPC)Tcp | homozygote | E15.5 | N/A * | ||
| increased startle reflex | 1 supporting dataset | Zfp462em1(IMPC)Tcp | heterozygote | Early adult | 1.24x10-7 | ||
| increased total body fat amount | 2 supporting datasets | Zfp462em1(IMPC)Tcp | heterozygote | Early adult | 2.34x10-7 | ||
| impaired glucose tolerance | 1 supporting dataset | Zfp462em1(IMPC)Tcp | heterozygote | Early adult | 3.4x10-5 | ||
| abnormal embryo size | 1 supporting dataset | Zfp462em1(IMPC)Tcp | homozygote | E15.5 | N/A * |
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Human diseases caused by Zfp462 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Zfp462.
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| Zfp462em1(IMPC)Tcp | Intra-exon deletion | | mouse |
| Zfp462tm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Zfp462tm459785(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Zfp462tm459827(L1L2_GT2_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |