Zfp462 | zinc finger protein 462

GeneMGI:107690Synonyms: Zfpip, Gt4-2, +1 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Embryo Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging

13 No significant impact

4 Not tested

Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance3 supporting datasetsZfp462em1(IMPC)TcphomozygoteEarly adultN/A * 
decreased lean body mass2 supporting datasetsZfp462em1(IMPC)TcpheterozygoteEarly adult1.14x10-10 
thrombocytopenia1 supporting datasetZfp462em1(IMPC)TcpheterozygoteEarly adult5.71x10-8 
edema1 supporting datasetZfp462em1(IMPC)TcphomozygoteE15.5N/A * 
increased startle reflex1 supporting datasetZfp462em1(IMPC)TcpheterozygoteEarly adult1.24x10-7 
increased total body fat amount2 supporting datasetsZfp462em1(IMPC)TcpheterozygoteEarly adult2.34x10-7 
impaired glucose tolerance1 supporting datasetZfp462em1(IMPC)TcpheterozygoteEarly adult3.4x10-5 
abnormal embryo size1 supporting datasetZfp462em1(IMPC)TcphomozygoteE15.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Zfp462em1(IMPC)TcpIntra-exon deletionmouse
Zfp462tm1(KOMP)MbpReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Zfp462tm459785(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Zfp462tm459827(L1L2_GT2_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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