Hmgcs1 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

GeneMGI:107592Synonyms: B130032C06Rik

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hearing/vestibular/ear Mortality/aging

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal auditory brainstem response	1 supporting dataset	Hmgcs1^em1(IMPC)J	heterozygote	Early adult	9.62x10^-11
increased circulating alanine transaminase level	1 supporting dataset	Hmgcs1^em1(IMPC)J	heterozygote	Early adult	1.61x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Hmgcs1^em1(IMPC)J	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hmgcs1.

Associated images

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Histopathology

There is no histopathology data found for Hmgcs1.

IMPC related publications

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External links

No external links available for Hmgcs1.

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*Hmgcs1^em1(IMPC)J*	Exon Deletion	‌	mouse

My Genes