Nab2 | Ngfi-A binding protein 2

GeneMGI:107563

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Liver/biliary system Behavior/neurological

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating HDL cholesterol level	1 supporting dataset	Nab2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.64x10^-7
hyperactivity	5 supporting datasets	Nab2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.59x10^-23
abnormal contextual conditioning behavior	4 supporting datasets	Nab2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.65x10^-5
increased vertical activity	1 supporting dataset	Nab2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.71x10^-18
increased anxiety-related response	1 supporting dataset	Nab2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.9x10^-5
abnormal cued conditioning behavior	1 supporting dataset	Nab2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.46x10^-14
abnormal behavior	2 supporting datasets	Nab2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.68x10^-6
decreased circulating cholesterol level	1 supporting dataset	Nab2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.1x10^-7
abnormal liver morphology	1 supporting dataset	Nab2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased locomotor activity	2 supporting datasets	Nab2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.65x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nab2.

Associated images

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Histopathology

There is no histopathology data found for Nab2.

IMPC related publications

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External links

No external links available for Nab2.

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*Nab2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Nab2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nab2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nab2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Nab2^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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