Art1 | ADP-ribosyltransferase 1

GeneMGI:107511Synonyms: Yac-1, ADPRT

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Integument Hematopoietic system Behavior/neurological

12 No significant impact

7 Not tested

Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased basophil cell number1 supporting datasetArt1tm1b(EUCOMM)WtsihomozygoteEarly adult8.03x10-7 
decreased exploration in new environment1 supporting datasetArt1tm1b(EUCOMM)WtsihomozygoteEarly adult7.93x10-6 
decreased grip strength1 supporting datasetArt1tm1b(EUCOMM)WtsihomozygoteEarly adult6.78x10-7 
decreased circulating sodium level1 supporting datasetArt1tm1b(EUCOMM)WtsihomozygoteEarly adult4.75x10-6 
decreased circulating calcium level1 supporting datasetArt1tm1b(EUCOMM)WtsihomozygoteEarly adult7.14x10-7 
increased circulating alanine transaminase level1 supporting datasetArt1tm1b(EUCOMM)WtsihomozygoteEarly adult8.18x10-6 
abnormal skin morphology1 supporting datasetArt1tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
enlarged lymph nodes1 supporting datasetArt1tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Art1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Art1tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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