Kcnj11 | potassium inwardly rectifying channel, subfamily J, member 11

GeneMGI:107501Synonyms: Kir6.2

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hearing/vestibular/ear Hematopoietic system

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

13Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



impaired glucose tolerance	1 supporting dataset	Kcnj11^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.99x10^-20
decreased hemoglobin content	1 supporting dataset	Kcnj11^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.02x10^-10
abnormal ear morphology	1 supporting dataset	Kcnj11^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.16x10^-5
decreased fasting circulating glucose level	1 supporting dataset	Kcnj11^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.26x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kcnj11.

Associated images

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Histopathology

There is no histopathology data found for Kcnj11.

IMPC related publications

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External links

No external links available for Kcnj11.

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*Kcnj11^em1H*	Point Mutation	‌	mouse
*Kcnj11^em2H*	Point Mutation	‌	mouse
*Kcnj11^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Kcnj11^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Kcnj11^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Kcnj11^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

My Genes