Kcnj11 | potassium inwardly rectifying channel, subfamily J, member 11

GeneMGI:107501Synonyms: Kir6.2

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Hearing/vestibular/ear Hematopoietic system

14 No significant impact

7 Not tested

Gene metrics:4Significant phenotypes
13Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

impaired glucose tolerance1 supporting datasetKcnj11tm1b(EUCOMM)WtsihomozygoteEarly adult2.99x10-20 
decreased hemoglobin content1 supporting datasetKcnj11tm1b(EUCOMM)WtsihomozygoteEarly adult1.02x10-10 
abnormal ear morphology1 supporting datasetKcnj11tm1b(EUCOMM)WtsihomozygoteEarly adult5.16x10-5 
decreased fasting circulating glucose level1 supporting datasetKcnj11tm1b(EUCOMM)WtsihomozygoteEarly adult4.26x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a100% (2/2)0.19% (1/533)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a100% (2/2)0.56% (3/532)
cerebral cortexheterozygoten/a100% (2/2)0.41% (2/491)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Kcnj11em1HPoint Mutationmouse
Kcnj11em2HPoint Mutationmouse
Kcnj11tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Kcnj11tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Kcnj11tm1c(EUCOMM)WtsiWild type floxed exon (post-Flp)mouse
Kcnj11tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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