Myl12b | myosin, light chain 12B, regulatory

GeneMGI:107494Synonyms: Mylc2b, RLC-B, +1 more

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased erythrocyte cell number	1 supporting dataset	Myl12b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.03x10^-6
decreased hematocrit	1 supporting dataset	Myl12b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.6x10^-6
decreased mean corpuscular volume	1 supporting dataset	Myl12b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1x10^-22
decreased circulating fructosamine level	1 supporting dataset	Myl12b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.89x10^-9
decreased circulating total protein level	1 supporting dataset	Myl12b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.47x10^-5
decreased circulating bilirubin level	1 supporting dataset	Myl12b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.79x10^-5
decreased hemoglobin content	1 supporting dataset	Myl12b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.49x10^-11
increased circulating sodium level	1 supporting dataset	Myl12b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.75x10^-6
decreased mean corpuscular hemoglobin	1 supporting dataset	Myl12b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.56x10^-16
decreased circulating serum albumin level	1 supporting dataset	Myl12b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.63x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Myl12b.

Associated images

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Histopathology

There is no histopathology data found for Myl12b.

IMPC related publications

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External links

No external links available for Myl12b.

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*Myl12b^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse

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