Stim1 | stromal interaction molecule 1
Physiological systems
22 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Immune system Integument Embryo Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging Renal/urinary system
12 No significant impact
2 Not tested
Data collections
Gene metrics:22Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| microphthalmia | 1 supporting dataset | Stim1em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| abnormal placenta morphology | 1 supporting dataset | Stim1em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Stim1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Stim1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal lymph node morphology | 1 supporting dataset | Stim1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Stim1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| microphthalmia | 1 supporting dataset | Stim1em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal placenta morphology | 1 supporting dataset | Stim1em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Stim1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| increased neutrophil cell number | 1 supporting dataset | Stim1em1(IMPC)Mbp | heterozygote | Early adult | 9.84x10-5 |
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Human diseases caused by Stim1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Stim1.
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| Stim1em1(IMPC)Mbp | Exon Deletion | | mouse |
| Stim1tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Stim1tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |