Cd38 | CD38 antigen
Physiological systems
22 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system
18 No significant impact
2 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased memory-marker CD4-positive NK T cell number | 1 supporting dataset | Cd38em1(IMPC)Ccpcz | homozygote | Early adult | 1.48x10-10 | ||
| abnormal spleen morphology | 2 supporting datasets | Cd38em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased T-helper cell number | 1 supporting dataset | Cd38em1(IMPC)Ccpcz | homozygote | Early adult | 2.42x10-5 | ||
| abnormal thymus morphology | 1 supporting dataset | Cd38em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged spleen | 2 supporting datasets | Cd38em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased CD4-positive NK T cell number | 1 supporting dataset | Cd38em1(IMPC)Ccpcz | homozygote | Early adult | 1.28x10-10 | ||
| increased effector memory CD8-positive, alpha-beta T cell number | 1 supporting dataset | Cd38em1(IMPC)Ccpcz | homozygote | Early adult | 9.76x10-5 | ||
| decreased NK T cell number | 1 supporting dataset | Cd38em1(IMPC)Ccpcz | homozygote | Early adult | 4.63x10-9 | ||
| decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | 1 supporting dataset | Cd38em1(IMPC)Ccpcz | homozygote | Early adult | 4.52x10-20 | ||
| decreased CD4-positive, alpha-beta T cell number | 1 supporting dataset | Cd38em1(IMPC)Ccpcz | homozygote | Early adult | 1.03x10-5 |
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Human diseases caused by Cd38 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cd38.
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| Cd38em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Cd38tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Cd38tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cd38tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |