Plcb4 | phospholipase C, beta 4

GeneMGI:107464Synonyms: A930039J07Rik, C230058B11Rik

Physiological systems

15 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Adipose tissue Growth/size/body region Hearing/vestibular/ear Liver/biliary system Behavior/neurological Skeleton Mortality/aging

6 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

3Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased lean body mass	1 supporting dataset	Plcb4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.19x10^-7
abnormal locomotor behavior	1 supporting dataset	Plcb4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4x10^-6
decreased locomotor activity	6 supporting datasets	Plcb4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.92x10^-10
increased vertical activity	1 supporting dataset	Plcb4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.44x10^-9
preweaning lethality, incomplete penetrance	1 supporting dataset	Plcb4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
hydrometra	1 supporting dataset	Plcb4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased grip strength	2 supporting datasets	Plcb4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.01x10^-6
decreased total body fat amount	1 supporting dataset	Plcb4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.75x10^-7
increased bone mineral content	1 supporting dataset	Plcb4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.1x10^-10
abnormal uterus morphology	1 supporting dataset	Plcb4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Plcb4.

Associated images

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Histopathology

There is no histopathology data found for Plcb4.

IMPC related publications

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External links

No external links available for Plcb4.

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*Plcb4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Plcb4^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Plcb4^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Plcb4^{tm39490(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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