Cox6b1 | cytochrome c oxidase, subunit 6B1

GeneMGI:107460Synonyms: 2010000G05Rik

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Immune system Integument Endocrine/exocrine gland Embryo Growth/size/body region Vision/eye Hematopoietic system Cardiovascular system Mortality/aging

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Cox6b1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Cox6b1^em1(IMPC)Tcp	homozygote	E12.5	N/A ^*
abnormal sinus arrhythmia	1 supporting dataset	Cox6b1^em1(IMPC)Tcp	heterozygote	Early adult	1.13x10^-8
absent adrenal gland	1 supporting dataset	Cox6b1^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
increased spleen weight	1 supporting dataset	Cox6b1^em1(IMPC)Tcp	heterozygote	Early adult	8.62x10^-5
abnormal skin morphology	1 supporting dataset	Cox6b1^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
microphthalmia	1 supporting dataset	Cox6b1^em1(IMPC)Tcp	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cox6b1.

Associated images

1 images

Electrocardiogram (ECG)

Waveform Image

47 images

Eye Morphology

Images Ophthalmoscopy

6 images

Eye Morphology

Images Slit Lamp

14 images

Gross Morphology Embryo E12.5

Images

4 images

Gross Morphology Embryo E14.5-E15.5

Images

8 images

Gross Pathology and Tissue Collection

Images

3 images

Histopathology

Images

Download files

Immunophenotyping

Panel A FCS file(s)

Download files

Immunophenotyping

Panel B FCS file(s)

10 images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 images

X-ray

XRay Images Skull Lateral Orientation

10 images

X-ray

XRay Images Whole Body Dorso Ventral

10 images

X-ray

XRay Images Whole Body Lateral Orientation

Human diseases caused by Cox6b1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.



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Histopathology

This gene doesn't have any significant Histopathology hits. Click here to see the raw data

IMPC related publications

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External links

No external links available for Cox6b1.

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*Cox6b1^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Cox6b1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cox6b1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes

Cox6b1 | cytochrome c oxidase, subunit 6B1

Physiological systems

9 Significantly impacted by the knock-out

12 No significant impact

3 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

Electrocardiogram (ECG)

Eye Morphology

Eye Morphology

Gross Morphology Embryo E12.5

Gross Morphology Embryo E14.5-E15.5

Gross Pathology and Tissue Collection

Histopathology

Immunophenotyping

Immunophenotyping

X-ray

X-ray

X-ray

X-ray

Human diseases caused by Cox6b1 mutations

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data