Efna5 | ephrin A5

GeneMGI:107444Synonyms: LERK-7, Ephrin-A5, +4 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Growth/size/body region Vision/eye Behavior/neurological Renal/urinary system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased grip strength	1 supporting dataset	Efna5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.46x10^-5
enlarged adrenal glands	1 supporting dataset	Efna5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal lens morphology	4 supporting datasets	Efna5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.24x10^-24
abnormal behavior	1 supporting dataset	Efna5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.49x10^-5
enlarged uterus	1 supporting dataset	Efna5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
polycystic kidney	1 supporting dataset	Efna5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
cornea opacity	1 supporting dataset	Efna5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.63x10^-5
decreased locomotor activity	2 supporting datasets	Efna5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.12x10^-5
irregularly shaped pupil	1 supporting dataset	Efna5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.69x10^-5
abnormal cornea morphology	1 supporting dataset	Efna5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.58x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Efna5.

Associated images

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Histopathology

There is no histopathology data found for Efna5.

IMPC related publications

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External links

No external links available for Efna5.

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*Efna5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Efna5^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Efna5^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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