Efna5 | ephrin A5
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Growth/size/body region Vision/eye Behavior/neurological Renal/urinary system
13 No significant impact
4 Not tested
Data collections
Gene metrics:18Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased grip strength | 1 supporting dataset | Efna5tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.46x10-5 | ||
| enlarged adrenal glands | 1 supporting dataset | Efna5tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal lens morphology | 4 supporting datasets | Efna5tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.24x10-24 | ||
| abnormal behavior | 1 supporting dataset | Efna5tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.49x10-5 | ||
| enlarged uterus | 1 supporting dataset | Efna5tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| polycystic kidney | 1 supporting dataset | Efna5tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| cornea opacity | 1 supporting dataset | Efna5tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.63x10-5 | ||
| decreased locomotor activity | 2 supporting datasets | Efna5tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.12x10-5 | ||
| irregularly shaped pupil | 1 supporting dataset | Efna5tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.69x10-5 | ||
| abnormal cornea morphology | 1 supporting dataset | Efna5tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.58x10-5 |
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Human diseases caused by Efna5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Efna5.
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| Efna5tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Efna5tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Efna5tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |