Lefty1 | left right determination factor 1

GeneMGI:107405Synonyms: Ebaf, Stra3, +2 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Behavior/neurological Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Lefty1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal gait	1 supporting dataset	Lefty1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.85x10^-9
increased total body fat amount	1 supporting dataset	Lefty1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.45x10^-5
increased circulating potassium level	1 supporting dataset	Lefty1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	9.05x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lefty1.

Associated images

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Histopathology

There is no histopathology data found for Lefty1.

IMPC related publications

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External links

No external links available for Lefty1.

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*Lefty1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Lefty1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Lefty1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Lefty1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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