Tbr1 | T-box brain transcription factor 1
Physiological systems
23 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Nervous system Mortality/aging Cardiovascular system
18 No significant impact
1 Not tested
Gene metrics:6Significant phenotypes
3Associated diseases
Expression examined in:73Adult tissues
68Embryo tissues
| hemorrhage | 1 supporting dataset | Tbr1tm1.1(KOMP)Mbp | heterozygote | E15.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Tbr1tm1.1(KOMP)Mbp | homozygote | Early adult | N/A * | ||
| decreased circulating glucose level | 1 supporting dataset | Tbr1tm1.1(KOMP)Mbp | heterozygote | Early adult | 6.73x10-7 | ||
| spina bifida | 1 supporting dataset | Tbr1tm1.1(KOMP)Mbp | homozygote | E15.5 | N/A * | ||
| decreased circulating creatinine level | 1 supporting dataset | Tbr1tm1.1(KOMP)Mbp | heterozygote | Early adult | 7.43x10-10 | ||
| decreased blood urea nitrogen level | 1 supporting dataset | Tbr1tm1.1(KOMP)Mbp | heterozygote | Early adult | 8.66x10-5 | ||
| spina bifida | 1 supporting dataset | Tbr1tm1.1(KOMP)Mbp | heterozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Tbr1tm1.1(KOMP)Mbp | homozygote | E15.5 | N/A * |
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External links
No external links available for Tbr1.
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| Tbr1tm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |
| Tbr1tm1.1(KOMP)Mbp | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Tbr1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Tbr1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |