Clk1 | CDC-like kinase 1

GeneMGI:107403Synonyms: Clk1, STY

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Behavior/neurological

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal retina morphology	2 supporting datasets	Clk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.61x10^-6
increased circulating creatinine level	1 supporting dataset	Clk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.45x10^-5
decreased circulating calcium level	1 supporting dataset	Clk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.82x10^-6
increased startle reflex	3 supporting datasets	Clk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.25x10^-10
tremors	1 supporting dataset	Clk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.66x10^-5
decreased granulocyte number	1 supporting dataset	Clk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.03x10^-6
increased circulating phosphate level	1 supporting dataset	Clk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.42x10^-6
abnormal response to tactile stimuli	1 supporting dataset	Clk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.7x10^-6
increased IgG2b level	1 supporting dataset	Clk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.43x10^-8
thrombocytosis	1 supporting dataset	Clk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.34x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Clk1.

Associated images

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Histopathology

There is no histopathology data found for Clk1.

IMPC related publications

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External links

No external links available for Clk1.

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*Clk1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Clk1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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