Pitx1 | paired-like homeodomain transcription factor 1

GeneMGI:107374Synonyms: Bft, P-OTX, +2 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Integument Limbs/digits/tail Vision/eye Skeleton Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal joint morphology	1 supporting dataset	Pitx1^{em1(IMPC)Wtsi}	heterozygote	Early adult	4.34x10^-13
abnormal femur morphology	1 supporting dataset	Pitx1^{em1(IMPC)Wtsi}	heterozygote	Early adult	6.01x10^-9
vertebral transformation	1 supporting dataset	Pitx1^{em1(IMPC)Wtsi}	heterozygote	Early adult	7.17x10^-5
abnormal cornea morphology	1 supporting dataset	Pitx1^{em1(IMPC)Wtsi}	heterozygote	Early adult	4.22x10^-8
abnormal digit morphology	3 supporting datasets	Pitx1^{em1(IMPC)Wtsi}	heterozygote	Early adult	4.39x10^-8
abnormal nail morphology	1 supporting dataset	Pitx1^{em1(IMPC)Wtsi}	heterozygote	Early adult	8.67x10^-6
abnormal tibia morphology	1 supporting dataset	Pitx1^{em1(IMPC)Wtsi}	heterozygote	Early adult	4.71x10^-16
abnormal autopod morphology	1 supporting dataset	Pitx1^{em1(IMPC)Wtsi}	heterozygote	Early adult	4.08x10^-5
polysyndactyly	1 supporting dataset	Pitx1^{em1(IMPC)Wtsi}	heterozygote	Early adult	5.63x10^-8
preweaning lethality, complete penetrance	1 supporting dataset	Pitx1^{em1(IMPC)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pitx1.

Associated images

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Histopathology

There is no histopathology data found for Pitx1.

IMPC related publications

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External links

No external links available for Pitx1.

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*Pitx1^{em1(IMPC)Wtsi}*	Deletion	‌	mouse
*Pitx1^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell
*Pitx1^{tm208889(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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