Il17a | interleukin 17A
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Immune system Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Renal/urinary system
14 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal spleen morphology | 1 supporting dataset | Il17aem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| small liver | 1 supporting dataset | Il17aem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased freezing behavior | 1 supporting dataset | Il17aem1(IMPC)Mbp | homozygote | Early adult | 1.03x10-9 | ||
| small kidney | 1 supporting dataset | Il17aem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Il17aem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal liver morphology | 1 supporting dataset | Il17aem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| enlarged spleen | 1 supporting dataset | Il17aem1(IMPC)Mbp | homozygote | Early adult | N/A * |
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Human diseases caused by Il17a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Il17a.
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| Il17aem1(IMPC)Mbp | Exon Deletion | | mouse |
| Il17atm88656(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |