Stxbp1 | syntaxin binding protein 1

GeneMGI:107363Synonyms: N-sec1, Unc18h, +5 more

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Hearing/vestibular/ear Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

3Associated diseases

Expression examined in:48Adult tissues

52Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



hyperactivity	6 supporting datasets	Stxbp1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.43x10^-13
impaired glucose tolerance	1 supporting dataset	Stxbp1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.07x10^-7
increased thigmotaxis	4 supporting datasets	Stxbp1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.98x10^-5
hemorrhage	1 supporting dataset	Stxbp1^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
abnormal embryo size	1 supporting dataset	Stxbp1^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
edema	1 supporting dataset	Stxbp1^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
decreased hematocrit	1 supporting dataset	Stxbp1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.45x10^-7
abnormal auditory brainstem response	1 supporting dataset	Stxbp1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.09x10^-5
increased exploration in new environment	1 supporting dataset	Stxbp1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.58x10^-8
preweaning lethality, complete penetrance	1 supporting dataset	Stxbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Stxbp1.

Associated images

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Histopathology

There is no histopathology data found for Stxbp1.

IMPC related publications

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External links

No external links available for Stxbp1.

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*Stxbp1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Stxbp1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Stxbp1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Stxbp1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Stxbp1^{tm26688(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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