Bmpr1b | bone morphogenetic protein receptor, type 1B
Physiological systems
20 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Limbs/digits/tail Nervous system Vision/eye Liver/biliary system Behavior/neurological Skeleton
11 No significant impact
4 Not tested
Data collections
Gene metrics:17Significant phenotypes
8Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased grip strength | 4 supporting datasets | Bmpr1bem1(IMPC)Mbp | homozygote | Early adult | 3.51x10-83 | ||
| small seminal vesicle | 1 supporting dataset | Bmpr1bem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal vitreous body morphology | 1 supporting dataset | Bmpr1bem1(IMPC)Mbp | homozygote | Early adult | 6.32x10-6 | ||
| abnormal liver morphology | 1 supporting dataset | Bmpr1bem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal seminal vesicle morphology | 1 supporting dataset | Bmpr1bem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased freezing behavior | 1 supporting dataset | Bmpr1bem1(IMPC)Mbp | homozygote | Early adult | 7.8x10-15 | ||
| abnormal optic disk morphology | 1 supporting dataset | Bmpr1bem1(IMPC)Mbp | homozygote | Early adult | 5.18x10-17 | ||
| abnormal bone structure | 1 supporting dataset | Bmpr1bem1(IMPC)Mbp | homozygote | Early adult | 4.15x10-7 | ||
| abnormal testis morphology | 1 supporting dataset | Bmpr1bem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal autopod morphology | 2 supporting datasets | Bmpr1bem1(IMPC)Mbp | homozygote | Early adult | 2.72x10-5 |
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Human diseases caused by Bmpr1b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Bmpr1b.
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| Bmpr1bem1(IMPC)Mbp | Inter-exon deletion | | mouse |