Ppp3ca | protein phosphatase 3, catalytic subunit, alpha isoform

GeneMGI:107164Synonyms: CnA, Calna, +5 more

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Growth/size/body region Hematopoietic system Behavior/neurological

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

5Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased body weight	2 supporting datasets	Ppp3ca^{tm2e(EUCOMM)Wtsi}	homozygote	Early adult	2.12x10^-6
increased blood urea nitrogen level	1 supporting dataset	Ppp3ca^{tm2e(EUCOMM)Wtsi}	homozygote	Early adult	1.67x10^-6
abnormal tail movements	1 supporting dataset	Ppp3ca^{tm2e(EUCOMM)Wtsi}	homozygote	Early adult	5.6x10^-6
decreased circulating magnesium level	1 supporting dataset	Ppp3ca^{tm2e(EUCOMM)Wtsi}	homozygote	Early adult	3.4x10^-5
decreased mean corpuscular volume	1 supporting dataset	Ppp3ca^{tm2e(EUCOMM)Wtsi}	homozygote	Early adult	3.84x10^-5
abnormal coat/hair pigmentation	1 supporting dataset	Ppp3ca^{tm2e(EUCOMM)Wtsi}	homozygote	Early adult	2.34x10^-6
decreased circulating amylase level	1 supporting dataset	Ppp3ca^{tm2e(EUCOMM)Wtsi}	homozygote	Early adult	6.22x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ppp3ca.

Associated images

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Histopathology

There is no histopathology data found for Ppp3ca.

IMPC related publications

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External links

No external links available for Ppp3ca.

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*Ppp3ca^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Ppp3ca^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Ppp3ca^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Ppp3ca^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell mouse
*Ppp3ca^{tm3e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Ppp3ca^{tm42411(L1L2_Pgk_PM)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Ppp3ca^{tm42411(L1L2_st1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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