Ppp3cb | protein phosphatase 3, catalytic subunit, beta isoform

GeneMGI:107163Synonyms: Cnab, CnAbeta, +3 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Hematopoietic system Cardiovascular system Renal/urinary system

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal kidney morphology	1 supporting dataset	Ppp3cb^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal heart left ventricle morphology	2 supporting datasets	Ppp3cb^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.8x10^-5
immune system phenotype	1 supporting dataset	Ppp3cb^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.54x10^-7
increased effector memory T-helper cell number	1 supporting dataset	Ppp3cb^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.96x10^-10
increased effector memory CD8-positive, alpha-beta T cell number	1 supporting dataset	Ppp3cb^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.06x10^-10
decreased T-helper cell number	1 supporting dataset	Ppp3cb^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.02x10^-5
decreased CD8-positive, alpha-beta T cell number	1 supporting dataset	Ppp3cb^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.5x10^-5
decreased CD4-positive NK T cell number	1 supporting dataset	Ppp3cb^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.97x10^-6
decreased CD4-positive, alpha-beta T cell number	1 supporting dataset	Ppp3cb^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.11x10^-6
decreased NK T cell number	1 supporting dataset	Ppp3cb^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.81x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ppp3cb.

Associated images

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Histopathology

There is no histopathology data found for Ppp3cb.

IMPC related publications

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External links

No external links available for Ppp3cb.

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*Ppp3cb^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Ppp3cb^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Ppp3cb^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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