Hmx2 | H6 homeobox 2

GeneMGI:107159Synonyms: Nkx5-2

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Growth/size/body region Hearing/vestibular/ear Skeleton Mortality/aging Renal/urinary system

16 No significant impact

3 Not tested

Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

abnormal kidney morphology2 supporting datasetsHmx2tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
enlarged kidney2 supporting datasetsHmx2tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
polycystic kidney2 supporting datasetsHmx2tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
increased bone mineral content1 supporting datasetHmx2tm1.1(KOMP)VlcghomozygoteEarly adult4.03x10-5 
abnormal auditory brainstem response1 supporting datasetHmx2tm1.1(KOMP)VlcghomozygoteEarly adult7.19x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetHmx2tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
increased kidney weight1 supporting datasetHmx2tm1.1(KOMP)VlcghomozygoteEarly adult8.88x10-41 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Hmx2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
mouse
Hmx2tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Hmx2tm100694(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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