Hmx2 | H6 homeobox 2
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Growth/size/body region Hearing/vestibular/ear Skeleton Mortality/aging Renal/urinary system
16 No significant impact
3 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| abnormal kidney morphology | 2 supporting datasets | Hmx2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| enlarged kidney | 2 supporting datasets | Hmx2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| polycystic kidney | 2 supporting datasets | Hmx2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased bone mineral content | 1 supporting dataset | Hmx2tm1.1(KOMP)Vlcg | homozygote | Early adult | 4.03x10-5 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Hmx2tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.19x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Hmx2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased kidney weight | 1 supporting dataset | Hmx2tm1.1(KOMP)Vlcg | homozygote | Early adult | 8.88x10-41 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 50% (1/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Hmx2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Hmx2.
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| Hmx2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Hmx2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Hmx2tm100694(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |