Efna4 | ephrin A4
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Behavior/neurological Renal/urinary system
14 No significant impact
6 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| abnormal sleep behavior | 1 supporting dataset | Efna4tm1.1(KOMP)Vlcg | homozygote | Early adult | 9.35x10-6 | ||
| abnormal cornea morphology | 1 supporting dataset | Efna4tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.61x10-5 | ||
| decreased circulating glucose level | 1 supporting dataset | Efna4tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.05x10-5 | ||
| impaired pupillary reflex | 1 supporting dataset | Efna4tm1.1(KOMP)Vlcg | homozygote | Early adult | 6.41x10-9 | ||
| decreased urine creatinine level | 1 supporting dataset | Efna4tm1.1(KOMP)Vlcg | homozygote | Early adult | 6.2x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Efna4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Efna4.
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| Efna4tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Efna4tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Efna4tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Efna4tm214483(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |