Gpld1 | glycosylphosphatidylinositol specific phospholipase D1

GeneMGI:106604Synonyms: 6330541J12Rik

Physiological systems

21 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Nervous system Hematopoietic system Cardiovascular system Mortality/aging Renal/urinary system

10 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



small testis	1 supporting dataset	Gpld1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Gpld1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Gpld1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased heart weight	2 supporting datasets	Gpld1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.82x10^-8
increased circulating alkaline phosphatase level	1 supporting dataset	Gpld1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.21x10^-39
enlarged heart	1 supporting dataset	Gpld1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased lean body mass	2 supporting datasets	Gpld1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.29x10^-7
increased brain weight	1 supporting dataset	Gpld1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.71x10^-5
increased spleen weight	1 supporting dataset	Gpld1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.11x10^-5
enlarged kidney	1 supporting dataset	Gpld1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gpld1.

Associated images

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Histopathology

There is no histopathology data found for Gpld1.

IMPC related publications

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External links

No external links available for Gpld1.

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*Gpld1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Gpld1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Gpld1^{tm299268(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Gpld1^{tm38869(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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