Rufy3 | RUN and FYVE domain containing 3
Physiological systems
16 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Digestive/alimentary Mortality/aging
14 No significant impact
8 Not tested
Data collections
Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:76Adult tissues
25Embryo tissues
| abnormal stomach morphology | 1 supporting dataset | Rufy3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Rufy3tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Wholemount images | n/a | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | n/a | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | n/a | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (4/4) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Wholemount images | n/a | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 75% (3/4) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (4/4) | 0.41% (2/491) |
Human diseases caused by Rufy3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rufy3.
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| Rufy3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Rufy3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rufy3tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rufy3tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |