Vcf1 | VCP nuclear cofactor family member 1

GeneMGI:106351Synonyms: Fam104a, D11Wsu99e

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating bilirubin level	1 supporting dataset	Vcf1^{tm2a(EUCOMM)Wtsi}	homozygote	Early adult	9.74x10^-8
decreased body weight	1 supporting dataset	Vcf1^{tm2a(EUCOMM)Wtsi}	homozygote	Early adult	3.84x10^-5
abnormal behavior	1 supporting dataset	Vcf1^{tm2a(EUCOMM)Wtsi}	homozygote	Early adult	4.52x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Vcf1^{tm2a(EUCOMM)Wtsi}	homozygote	Early adult	3.41x10^-5
increased lactate dehydrogenase level	1 supporting dataset	Vcf1^{tm2a(EUCOMM)Wtsi}	homozygote	Early adult	1.22x10^-7
increased leukocyte cell number	1 supporting dataset	Vcf1^{tm2a(EUCOMM)Wtsi}	homozygote	Early adult	2.82x10^-7
increased circulating aspartate transaminase level	1 supporting dataset	Vcf1^{tm2a(EUCOMM)Wtsi}	homozygote	Early adult	5.43x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Vcf1.

Associated images

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Histopathology

There is no histopathology data found for Vcf1.

IMPC related publications

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External links

No external links available for Vcf1.

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*Vcf1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Vcf1^{tm132(pL1L2_GT2_DelLacZ_bsd)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Vcf1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Vcf1^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Vcf1^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Vcf1^{tm3a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Vcf1^{tm3e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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