Med10 | mediator complex subunit 10

GeneMGI:106331Synonyms: D13Wsu50e

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Hearing/vestibular/ear Hematopoietic system Skeleton Mortality/aging

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased erythrocyte cell number1 supporting datasetMed10em1(IMPC)JheterozygoteEarly adult1.65x10-5 
increased mean corpuscular volume1 supporting datasetMed10em1(IMPC)JheterozygoteEarly adult5.49x10-5 
preweaning lethality, complete penetrance1 supporting datasetMed10em1(IMPC)JhomozygoteEarly adultN/A * 
decreased bone mineral content1 supporting datasetMed10em1(IMPC)JheterozygoteEarly adult1.24x10-6 
abnormal auditory brainstem response1 supporting datasetMed10em1(IMPC)JheterozygoteEarly adult3.82x10-5 
decreased mean corpuscular hemoglobin concentration1 supporting datasetMed10em1(IMPC)JheterozygoteEarly adult1.14x10-8 
embryonic lethality prior to organogenesis1 supporting datasetMed10em1(IMPC)JhomozygoteE9.5N/A * 
decreased hemoglobin content1 supporting datasetMed10em1(IMPC)JheterozygoteEarly adult4.39x10-5 
decreased bone mineral density1 supporting datasetMed10em1(IMPC)JheterozygoteEarly adult1.14x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Med10em1(IMPC)JExon Deletionmouse
Med10tm401784(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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