Med10 | mediator complex subunit 10
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Hearing/vestibular/ear Hematopoietic system Skeleton Mortality/aging
14 No significant impact
6 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased erythrocyte cell number | 1 supporting dataset | Med10em1(IMPC)J | heterozygote | Early adult | 1.65x10-5 | ||
| increased mean corpuscular volume | 1 supporting dataset | Med10em1(IMPC)J | heterozygote | Early adult | 5.49x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Med10em1(IMPC)J | homozygote | Early adult | N/A * | ||
| decreased bone mineral content | 1 supporting dataset | Med10em1(IMPC)J | heterozygote | Early adult | 1.24x10-6 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Med10em1(IMPC)J | heterozygote | Early adult | 3.82x10-5 | ||
| decreased mean corpuscular hemoglobin concentration | 1 supporting dataset | Med10em1(IMPC)J | heterozygote | Early adult | 1.14x10-8 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Med10em1(IMPC)J | homozygote | E9.5 | N/A * | ||
| decreased hemoglobin content | 1 supporting dataset | Med10em1(IMPC)J | heterozygote | Early adult | 4.39x10-5 | ||
| decreased bone mineral density | 1 supporting dataset | Med10em1(IMPC)J | heterozygote | Early adult | 1.14x10-5 |
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Human diseases caused by Med10 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Med10.
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| Med10em1(IMPC)J | Exon Deletion | | mouse |
| Med10tm401784(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |